Studies in Hodgkin's syndrome. XI The influence of normal serum and Hodgkin's serum on cellular growth and morphology in tissue culture.

serum. Lustig and Lyonnet (4) conclude that normal serum exhibits an inhibiting action and cancer serum a stimulating action on the growth of nor mal fibroblasts and myeloblasts in vitro. Norris and Majnarich (6), on the other hand, report that normal blood serum accelerates—and blood serum from cases of pernicious anemia, leukemia, and neoplastic disease inhibits—cell proliferation in nor mal bone marrow cultures in vitro, and they note that the opposite effect is observed in human and ¡miniaineoplastic tissues other than bone mar row. The accelerating substance of normal serum and the inhibiting substance of neoplastic disease serum are said to counteract each other in normal bone marrow cultures. Grand (2) has referred briefly to the effect of autogenous Hodgkin's serum on the growth char acteristics of Hodgkin's lymph nodes in vitro.